Israeli officials have over the past week issued dozens of demolition orders threatening "nearly every structure" in a part of the village of Khan al-Ahmar, the UN said.
The United Nations humanitarian coordinator for the Palestinian territories, Robert Piper, visited the village where the primary school is among 140 structures at risk of demolition.
"Khan al-Ahmar is one of the most vulnerable communities in the West Bank struggling to maintain a minimum standard of living in the face of intense pressure from the Israeli authorities to move," he said in a statement.
"This is unacceptable and it must stop."
Israel says the buildings were built without permits.
Signup to our newsletter and follow us on Facebook and Twitter!
The UN says such permits are all but impossible to obtain for Palestinians.
"In the past days construction termination warrants were served to illegal buildings in Khan Al Ahmar," Israel's defence ministry body responsible for the Palestinian territories said.
"The enforcement will take place in coordination with state directives and required legal certifications."
Israel has occupied the West Bank for 50 years in contravention of international law.
A number of traditionally nomadic Bedouin communities are based east of Jerusalem, where rights groups fear demolitions could eventually clear the way for further Israeli settlement construction.
This could partly divide the West Bank between north and south while further isolating the territory from Israeli-annexed east Jerusalem, which the Palestinians see as their future capital.
The UN says there are 46 communities in the central West Bank at risk of forcible transfer, ousting approximately 7,000 residents.