The Turkish flag-carrier said that it had suspended flights to Misrata, its only remaining destination in the country after it had earlier pulled its flights to the capital Tripoli as well as Benghazi and the inland desert city of Sebha.
"We have suspended our Misrata flights until further notice, due to operational issues," a company spokesman said in an email to AFP.
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"Turkish Airlines is not operating any scheduled flights to Libya at the moment," the spokesman added.
The country has descended into chaos since dictator Moamer Kadhafi was overthrown and killed in a 2011 NATO-backed uprising. It has rival governments and parliaments and is awash with arms and militias.
Libya's internationally recognised government said Monday that its aircraft bombed an oil tanker off the Islamist-held port of Derna, killing two crewmen, one of them Greek, and drawing condemnation from Athens.