Syria's ruling Baath party, headed by the country's embattled President Bashar al-Assad, announced on Monday that its top leadership would be replaced, including Vice President Farouk al-Sharaa.
Assad, meanwhile, called on the party to "develop" and work more closely with the people in order to help end the country's 27-month war, state media said.
The party's central committee "held a lengthy meeting... on Monday morning," at which "a new national leadership was chosen", the Baath party website said.
It published the names of 16 members of the new leadership, which included none of the party's old chiefs with the exception of Assad.
The website said Assad would remain the party's secretary general.
Sharaa, who has been Syria's vice president since 2006, will remain in office despite his removal from the party leadership.
Among those newly elected to the party leadership are parliament chief Jihad al-Laham and Prime Minister Wael al-Halqi.
"The party must develop in step with reality on the ground, and promote a culture of dialogue and voluntary action by the people," Assad said at the meeting, according to state news agency SANA.
He said the party needed "to put in place new... criteria for the selection of party representatives, in order for them to be able to achieve (society's) objectives... and to strengthen citizens' roles in order to overcome" the current crisis.
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Bassam Abu Abdullah, director of the Damascus Centre for Strategic Studies, said the overhaul was the result of deep-seated discontent within the Baath party.
"There has been a lot of criticism from within the base towards the leadership, which has been accused of being inflexible, both before and since the crisis," he said, referring to the Syrian uprising.
"A complete change indicates the failure of leadership and the dissatisfaction from within the Baath party base," he told AFP.
A second Syrian analyst, speaking on condition of anonymity, said the reshuffle was as a result of "the old leadership's inability to take the initiative and confront the crisis".
He noted that the newly appointed leaders include a former ambassador, ex-Syrian envoy to Egypt Yussef Ahmad, for the first time.
"They've decided to bring in a younger leadership that is seen as more open to the international community," he told AFP.
The overhaul means that for the first time none of the members of the party's leadership is a member of the Syrian intelligence forces.
The Baath party has been in power since March 8, 1963 and is the most powerful political party in Syria.
Monday's meeting of the party's central committee was the first since 2005, when much of the previous old guard was replaced.
The move comes against the backdrop of the ongoing conflict in Syria, which began in March 2011 with peaceful anti-government protests but has become a bloody civil war estimated to have killed more than 100,000 people.