A right-wing Israeli activist was shot and wounded in west Jerusalem on Wednesday, police said, adding that the motive for the attack remained unclear.
The assailant, who was riding a motorbike and wearing a helmet, sped off after the shooting, police spokeswoman Luba Samri said.
"It is still too early to determine the motive of this attack," she said, adding that police roadblocks had been set up across Jerusalem in a bid to catch the shooter.
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Public radio said that the wounded man -- identified as Yehuda Glick and said to be in his fifties -- was a right-wing activist who had just attended a conference at the Menachem Begin Heritage Centre about Jewish claims to the Al-Aqsa Mosque compound.
Revered by Jews as the Temple Mount, the Al-Aqsa compound is Islam's third holiest site and one of the most sensitive flashpoints of the Arab-Israeli conflict.
Jerusalem's Israeli mayor, Nir Barkat, said on the radio that the shooting was "a terrorist attack" amid a recent spike in tensions over Al-Aqsa.
Reports Israel is considering allowing Jews to pray at the sprawling site in the Old City have triggered weeks of intermittent clashes.