Jordan's opposition Islamists said on Wednesday the Palestinians have "a near-zero chance" of gaining full United Nations membership.
"It's a near-zero chance. Even if it succeeds, the reality on the ground will not change because the United Nations has always been incapable of imposing its resolutions on Israel," the Muslim Brotherhood said on its website.
"We support the creation of an independent Palestinian state, but Palestinian rights should not be compromised in any way."
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Palestinian president Mahmud Abbas is expected on Friday to present to UN chief Ban Ki-moon a request for UN membership for a state of Palestine on the lines which existed before the 1967 Six Day War.
Israel strongly opposes the move and the United States, as a permanent member of the Security Council, has vowed to veto any application, which the council must approve.
"The complete failure of Palestinian-Israeli talks has pushed the Palestinian leadership to go to the United Nations," the Islamists said.
"The Muslim Brotherhood warns against this dangerous move, particularly that the Palestinians are seeking UN help in the absence of any other option, except the negotiations, which have already failed."
Israel and the United States insist that any Palestinian state must be brokered through direct Israeli-Palestinian talks.