"The World Changed," headlined reformist daily Etemad, calling Tuesday's agreement between Iran and the six world powers the "Diplomatic Revolution of July 14, 2015".
The Financial Asia carried the single word "Deal" beneath its masthead.
Under the agreement, Iran will be freed from the Western and UN sanctions that have crippled its economy, in return for curbs on its atomic programme for at least 10 years.
Financial daily Donyaye Eqtesad said Iran had "entered the post-sanctions age."
"Iran Siege Broken," headlined the moderate daily Ghanoon.
Another reformist daily, Ebtekar, lionised the deal's architect, Foreign Minister Mohammad Javad Zarif, with a front-page montage likening him to national hero Mohammad Mossadegh.
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A democratically elected prime minister who nationalised Iran's oil industry, Mossadegh was overthrown in a 1953 coup engineered by London and Washington that ushered in decades of autocracy.
It was left to conservative newspapers that opposed a nuclear deal throughout the long months of negotiations to sound a negative note.
Kayhan said that differing interpretations of the terms of the deal by Iranian President Hassan Rouhani and his US counterpart Barack Obama raised question marks about what had been agreed.
Its even more conservative rival Vatan-e-Ermooz was also sceptical, headlining: "Awaiting Implementation".
"The big challenge of such texts reveals itself during implementation," the paper warned in an editorial.
"The goals of the US in the post-deal stage are not necessarily those written in the nuclear agreement."