Hamas said Tuesday that "all Israelis" would be targeted after a deadly strike on a house in the southern city of Khan Yunis killed seven people, among them two teenagers.
"The Khan Yunis massacre... of children is a horrendous war crime, and all Israelis have now become legitimate targets for the resistance," Hamas spokesman Sami Abu Zuhri said in a statement, without elaborating.
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Medics said another 25 people were wounded in the strike.
Witnesses said a drone launched a warning flare, prompting relatives and neighbours to gather at the house as a human shield, but shortly afterwards an F-16 fired a missile which levelled the building.
Two teenage boys were among those killed, emergency services spokesman Ashraf al-Qudra said.