A crude bomb exploded on Saturday near a newly built hospital just minutes before it was inaugurated by Egypt's health minister, security officials said, adding that there were no casualties.
The device went off in the city of Kaft, 630 kilometres (around 390 miles) south of Cairo, before Adel al-Adawi arrived for the opening, the officials and state television reported.
The ceremony went ahead as planned.
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A wave of bombings and shootings has targeted Egypt's security forces since the army ousted Islamist president Mohamed Morsi last July.
Interior minister Mohamed Ibrahim escaped unhurt when a car bombing targeted his convoy last September in Cairo.
The military-installed authorities say militants have killed about 500 people since the overthrow of Morsi.
Most militant attacks have been in the restive Sinai Peninsula, but in recent months brazen attacks have also been launched farther afield in the Nile Delta and in the capital.