A group of 160 Syrians travelling in a fishing boat arrived in the southern Italian port of Crotone on Wednesday, the Italian ANSA news agency said.
The group from the conflict-torn country was made up mainly of families and included 76 men, 36 women and 48 children.
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Their boat was spotted about six kilometres or 10 miles offshore by a coastguard unit that escorted them to port.
The Syrians, all apparently in good health, were taken to a reception centre.
Some 2,000 kilometres (1,200 miles) of Mediterranean Sea separate Syria and Italy.